I had the exact same problem after updating my Pc to DirectX 9, game crashing all the time.
I searched for hours and hours before eventually stumbling on the secret, WHQL logo'd driver.
It took a while to figure out the combination of the uninstalling and reinstalling, but it was worth the time.
For the record my set up is Windows XP Pro, AMD Athlon XP 1.67 GHz chip and 1.25 GB Ram.
For the benefit of anyone else in the same boat here is what I did, then I uninstalled all my NVidia software and rebooted.
I then went to the http://www.nvidia.com website and downloaded a WHQL logo'd driver for Windows XP.
Firstly I reinstalled the Detonator file from Nvidia for Windows XP, I then opened the file containing the WHQL logo'd driver, obtainable here http://www.nvidia.com/page/search.html?keywords=WHQL+logo%27d+driver
I rebooted once again and my copy of Scrabble 2003 now works just fine, with no crashes.
I have my settings on Highest 32 (bit) and resolution 1280 by 1024, not sure if that's important but there it is.
You must have Service Pack 1 installed as a matter of point.
The other advice is to shut down any virus software both during installation and in gameplay, and shutdown any other uneeded programs clogging up the place.
I hope this helps and I will be happy to help where I can via e-mail.
sidthepig@btinternet.com
Sid